Antibiotic resistance is a serious and growing problem in human medicine. While medical overuse of antibiotics is a key part of the problem, mounting evidence indicates that the extensive use of antibiotics in agriculture also plays a significant role, by creating a massive reservoir of resistant bacteria that contaminate both the food chain and the environment. This Action Report requests ANA’s support for phasing out non-therapeutic use of medically important antibiotics as feed additives in order to protect their efficacy in human medicine. In addition, the Action Report requests ANA’s support for the Food and Drug Administration’s proposal to ban therapeutic use of fluoroquinolones in poultry, in order to protect efficacy of fluoroquinolones in treating serious food-borne illness in humans.