Just as steps are being taken to reduce overuse of antibiotics in human medicine, it is critical that steps be taken to eliminate overuse in agriculture. Hospitals are on the front lines of treating infections, and with sizable food service budgets, the health care sector is poised to tackle the antibiotic resistance crisis beyond the walls of clinical practice. Through its purchasing power and moral authority, the health care sector can change both markets and policies to protect antibiotics and prevent their overuse in animal agriculture.